PhytophthoraV1, Main, Exploration, bibRecord, 001877

Myb transcription factors in the oomycete Phytophthora with novel diversified DNA-binding domains and developmental stage-specific expression.

Identifieur interne : 001877 ( Main/Exploration ); précédent : 001876; suivant : 001878

Myb transcription factors in the oomycete Phytophthora with novel diversified DNA-binding domains and developmental stage-specific expression.

Auteurs : Qijun Xiang [États-Unis] ; Howard S. Judelson

Source :

Gene [ 1879-0038 ] ; 2010.

RBID : pubmed:20060444

Descripteurs français

English descriptors

KwdEn :
- Algal Proteins (chemistry), Algal Proteins (genetics), Algal Proteins (metabolism), Amino Acid Sequence (MeSH), Animals (MeSH), Binding Sites (MeSH), DNA (metabolism), Gene Expression Regulation, Developmental (MeSH), Humans (MeSH), Molecular Sequence Data (MeSH), Phylogeny (MeSH), Phytophthora (chemistry), Phytophthora (genetics), Phytophthora (growth & development), Phytophthora (metabolism), Protein Isoforms (chemistry), Protein Isoforms (genetics), Protein Isoforms (metabolism), Proto-Oncogene Proteins c-myb (chemistry), Proto-Oncogene Proteins c-myb (genetics), Proto-Oncogene Proteins c-myb (metabolism), Sequence Alignment (MeSH).
MESH :
- chemical , chemistry : Algal Proteins, Protein Isoforms, Proto-Oncogene Proteins c-myb.
- chemical , genetics : Algal Proteins, Protein Isoforms, Proto-Oncogene Proteins c-myb.
- chemical , metabolism : Algal Proteins, DNA, Protein Isoforms, Proto-Oncogene Proteins c-myb.
- chemistry : Phytophthora.
- genetics : Phytophthora.
- growth & development : Phytophthora.
- metabolism : Phytophthora.
- Amino Acid Sequence, Animals, Binding Sites, Gene Expression Regulation, Developmental, Humans, Molecular Sequence Data, Phylogeny, Sequence Alignment.

Abstract

Transcription factors containing two or three imperfect tandem repeats of the Myb DNA-binding domain (named R2R3 and R1R2R3, respectively) regulate important processes in growth and development. This study characterizes the structure, evolution, and expression of these proteins in the potato pathogen Phytophthora infestans and other oomycetes. P. infestans was found to encode five R2R3 and nine R1R2R3 transcription factor-like proteins, plus several with additional configurations of Myb domains. Sets of R2R3 and R1R2R3 orthologs are well-conserved in three Phytophthora species. Analyses of sites that bind DNA in canonical Myb transcription factors, such as mammalian c-Myb, revealed unusual diversification in the DNA recognition helices of the oomycete proteins. While oomycete R2R3 proteins contain c-Myb-like helices, R1R2R3 proteins exhibit either c-Myb-like or novel sequences. This suggests divergence in their DNA-binding specificities, which was confirmed by electrophoretic mobility shift assays. Eight of the P. infestans R2R3 and R1R2R3 genes are up-regulated during sporulation and three during zoospore release, which suggests their involvement in spore development. This is supported by the observation that an oomycete that does not form zoospores, Hyaloperonospora arabidopsidis, contains one-third fewer of these genes than Phytophthora.

DOI: 10.1016/j.gene.2009.12.006
PubMed: 20060444

Affiliations:

États-Unis

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Le document en format XML

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<author><name sortKey="Xiang, Qijun" sort="Xiang, Qijun" uniqKey="Xiang Q" first="Qijun" last="Xiang">Qijun Xiang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology and Microbiology, University of California, Riverside, 92521, USA.</nlm:affiliation>
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<term>Amino Acid Sequence (MeSH)</term>
<term>Animals (MeSH)</term>
<term>Binding Sites (MeSH)</term>
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<term>Gene Expression Regulation, Developmental (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Molecular Sequence Data (MeSH)</term>
<term>Phylogeny (MeSH)</term>
<term>Phytophthora (chemistry)</term>
<term>Phytophthora (genetics)</term>
<term>Phytophthora (growth & development)</term>
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<term>Protein Isoforms (chemistry)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>ADN (métabolisme)</term>
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<term>Données de séquences moléculaires (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Isoformes de protéines (composition chimique)</term>
<term>Isoformes de protéines (génétique)</term>
<term>Isoformes de protéines (métabolisme)</term>
<term>Phylogenèse (MeSH)</term>
<term>Phytophthora (composition chimique)</term>
<term>Phytophthora (croissance et développement)</term>
<term>Phytophthora (génétique)</term>
<term>Phytophthora (métabolisme)</term>
<term>Protéines d'algue (composition chimique)</term>
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<term>Protéines d'algue (métabolisme)</term>
<term>Protéines proto-oncogènes c-myb (composition chimique)</term>
<term>Protéines proto-oncogènes c-myb (génétique)</term>
<term>Protéines proto-oncogènes c-myb (métabolisme)</term>
<term>Régulation de l'expression des gènes au cours du développement (MeSH)</term>
<term>Sites de fixation (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
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</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Isoformes de protéines</term>
<term>Phytophthora</term>
<term>Protéines d'algue</term>
<term>Protéines proto-oncogènes c-myb</term>
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<term>Phytophthora</term>
<term>Protéines d'algue</term>
<term>Protéines proto-oncogènes c-myb</term>
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<term>Protéines d'algue</term>
<term>Protéines proto-oncogènes c-myb</term>
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<term>Binding Sites</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Sequence Alignment</term>
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<term>Phylogenèse</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Sites de fixation</term>
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<front><div type="abstract" xml:lang="en">Transcription factors containing two or three imperfect tandem repeats of the Myb DNA-binding domain (named R2R3 and R1R2R3, respectively) regulate important processes in growth and development. This study characterizes the structure, evolution, and expression of these proteins in the potato pathogen Phytophthora infestans and other oomycetes. P. infestans was found to encode five R2R3 and nine R1R2R3 transcription factor-like proteins, plus several with additional configurations of Myb domains. Sets of R2R3 and R1R2R3 orthologs are well-conserved in three Phytophthora species. Analyses of sites that bind DNA in canonical Myb transcription factors, such as mammalian c-Myb, revealed unusual diversification in the DNA recognition helices of the oomycete proteins. While oomycete R2R3 proteins contain c-Myb-like helices, R1R2R3 proteins exhibit either c-Myb-like or novel sequences. This suggests divergence in their DNA-binding specificities, which was confirmed by electrophoretic mobility shift assays. Eight of the P. infestans R2R3 and R1R2R3 genes are up-regulated during sporulation and three during zoospore release, which suggests their involvement in spore development. This is supported by the observation that an oomycete that does not form zoospores, Hyaloperonospora arabidopsidis, contains one-third fewer of these genes than Phytophthora.</div>
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<Abstract><AbstractText>Transcription factors containing two or three imperfect tandem repeats of the Myb DNA-binding domain (named R2R3 and R1R2R3, respectively) regulate important processes in growth and development. This study characterizes the structure, evolution, and expression of these proteins in the potato pathogen Phytophthora infestans and other oomycetes. P. infestans was found to encode five R2R3 and nine R1R2R3 transcription factor-like proteins, plus several with additional configurations of Myb domains. Sets of R2R3 and R1R2R3 orthologs are well-conserved in three Phytophthora species. Analyses of sites that bind DNA in canonical Myb transcription factors, such as mammalian c-Myb, revealed unusual diversification in the DNA recognition helices of the oomycete proteins. While oomycete R2R3 proteins contain c-Myb-like helices, R1R2R3 proteins exhibit either c-Myb-like or novel sequences. This suggests divergence in their DNA-binding specificities, which was confirmed by electrophoretic mobility shift assays. Eight of the P. infestans R2R3 and R1R2R3 genes are up-regulated during sporulation and three during zoospore release, which suggests their involvement in spore development. This is supported by the observation that an oomycete that does not form zoospores, Hyaloperonospora arabidopsidis, contains one-third fewer of these genes than Phytophthora.</AbstractText>
<CopyrightInformation>2010 Elsevier B.V. All rights reserved.</CopyrightInformation>
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Myb transcription factors in the oomycete Phytophthora with novel diversified DNA-binding domains and developmental stage-specific expression.

Myb transcription factors in the oomycete Phytophthora with novel diversified DNA-binding domains and developmental stage-specific expression.

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Abstract

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